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Hospitals and health systems have devoted significant time and resources to implement the U.S. Department of Health and Human Services Office of Inspector General’s guidance on building effective compliance programs. These providers face thorny questions on an almost daily basis regarding whether and how to investigate alleged compliance violations. The most problematic questions, however, often arise in the context of collecting and preserving the electronic documents that are critical to any robust internal investigation. This tutorial examines the unique issues presented by these investigations and provides expert insight on how to manage the related document collection challenges. In it, the presenters offer projections for government enforcement activity in the hospital industry going forward and discuss practical tips for organizing investigation teams and engaging expert consultants when needed.